How Efinia™ works

Efinia™ works both at the cellular level targeting only cancer cells, and at the tissue, organ, and organism levels using a 4-pronged approach:

Woman wearing a black tank top with digital graphics illustrating wireless charging and electromagnetic waves.

Cytoskeleton Disruption

Efinia™ alters the cancer cell's cytoskeleton making it unable to move

Metabolic Deprivation

Efinia™ metabolically deprive cells of energy to move and proliferate

Epithelial-to-Mesenchymal Transition (EMT) Reversal

Efinia™ reverses EMT preventing detachment

Immune Enhancement

Efinia™ boosts the immune system by attracting anti-tumor immune cells and dissuading pro-tumor immune cells

iEF Therapy Data

Diagram showing a box plot comparing the number of metastases between control and iEF groups, with control having more metastases. To the right, microscopic images of tissue slides labeled 'Control' and 'iEF,' with arrows pointing to tissue differences; each image has a 5 mm scale bar.

Pulmonary metastases are reduced

(in vivo  – 4T1 model)

Tumor volume is reduced

(in vivo  – 4T1 model)

Line graph comparing tumor volume over time between control and iEF groups. Control group shows higher tumor volume than iEF group, with significant difference noted after 16 days. The x-axis is labeled 'Days', and the y-axis is labeled 'Tumor volume (mm^3)'. Error bars are shown for both groups.

Tumor weight is reduced

(in vivo  – 4T1 model)

Boxplot showing tumor weight in grams for Control and iEF groups, with Control group having higher tumor weight; statistically significant difference indicated by asterisks.

Source: Induced electric fields inhibit breast cancer growth and metastasis by modulating the immune tumor microenvironment; https://biorxiv.org/cgi/content/short/2024.04.14.589256v1


Anti-mobility effects of iEF Therapy

Comparison of a cell before and after iEF therapy showing changes in actin cytoskeleton, with labels indicating filopodia enabling cell migration, note diffuse actin structure, and differences in actin cytoskeleton appearance.
Diagram showing immune cell interactions in breast tumor microenvironment and lung microenvironment, illustrating T cell responses, tumor cells, and immune cell types.

Immunomodulatory effects of iEF Therapy

“I am encouraged by the potential of induced Electric Field (iEF) Therapy as an innovative area of study for breast cancer. For decades, our approach to cancer treatment has rested on three fundamental pillars: surgery, systemic therapy, and radiation. The prospect of introducing a fourth modality—such as iEF Therapy—could be truly paradigm shifting, offering new hope for patients with difficult-to-treat cancers. I look forward to seeing how this technology may evolve and contribute to the future of oncology.”

- Dr. Sachin Jhawar, Radiation Oncologist

Publications

Induced electric fields inhibit breast cancer growth and metastasis by modulating the immune tumor microenvironment

Authors: Manish Charan, Travis H. Jones, Dinesh K. Ahirwar, Nandini Acharya, Vish V. Subramaniam, Ramesh K Ganju, and Jonathan W Song

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Directional Migration of Breast Cancer Cells Hindered by Induced Electric Fields May Be Due to Accompanying Alteration of Metabolic Activity

Authors: Travis H. Jones, PhD,  Kirti Kaul, PhD,  Ayush A. Garg, PhD,  Jonathan W. Song, PhD,  Ramesh K. Ganju, PhD,  and Vish V. Subramaniam, PhD

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Electromagnetic fields alter the motility of metastatic breast cancer cells

Authors: Ayush Arpit Garg, Travis H. Jones, Sarah M. Moss, Sanjay Mishra, Kirti Kaul, Dinesh K. Ahirwar, Jessica Ferree, Prabhat Kumar, Deepa Subramaniam, Ramesh K. Ganju, Vish V. Subramaniam & Jonathan W. Song

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Non-contact method for directing electrotaxis

Authors: Dinesh K. Ahirwar, Mohd W. Nasser, Travis H. Jones, Emily K. Sequin, Joseph D. West, Timothy L. Henthorne, Joshua Javor, Aniruddha M. Kaushik, Ramesh K. Ganju & Vish V. Subramaniam

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Related Publications

Evaluation of electrical properties of ex vivo human hepatic tissue with metastatic colorectal cancer

Authors: Varun Lochab, Travis H Jones1, Emily Alkandryl, Joseph D Westl, Mohamed H Abdel-Rahman2, Vish V Subramaniam, and Shaurya Prakash

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Ex vivo electrical impedance measurements on excised hepatic tissue from human patients with metastatic colorectal cancer

Authors: S. Prakash, M. P. Karnes, E. K. Sequin, J. D. West, C. L. Hitchcock, S. D. Nichols, M. Bloomston, S. R. Abdel-Misih, C. R. Schmidt, E. W. Martin Jr, S. P. Povoski, and V. V. Subramaniam

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